多塔利单抗Ⅲ期临床结果积极；曲妥珠单抗生物类似药获批上市

关键词

逆转录因子 内分泌 干扰素调节因子 饱和突变 PD-1检查点 曲妥珠单抗 多塔利单抗 恩沃利单抗  

#今日行业热点#

①Science：Genome editing with retroelements

观点：利用逆转录因子进行基因组编辑

DOI: 10.1126/science.adi3183

Genome editing with retroelements | Science

②Science：Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

基于CRISPR的功能筛选确定ZNF800是调控内分泌转录因子网络的关键因子

DOI: 10.1126/science.adi2246

Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation | Science

③Science Advances：IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance

干扰素调节因子1 (IRF1)通过调节自我更新和应激反应来支持造血干细胞(HSCs)的维持

DOI: 10.1126/sciadv.adg5391

IRF1 regulates self-renewal and stress responsiveness to support hematopoietic stem cell maintenance | Science Advances

④Science Advances：Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation

α-突触核蛋白(aSyn)饱和突变揭示了调节aSyn聚集的调节因子

DOI: 10.1126/sciadv.adh3457

Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation | Science Advances

⑤Science Advances：Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17

基质骨形态发生蛋白(BMP)信号通过IL-1和IL-17调节大肠黏蛋白的产生

DOI: 10.1126/sciadv.adi1827

Stromal BMP signaling regulates mucin production in the large intestine via interleukin-1/17 | Science Advances

⑥Science Translational Medicine：DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell–mediated antitumor immunity

DGKα/ζ抑制剂联合PD-1检查点疗法促进T细胞介导的抗肿瘤免疫

DOI: 10.1126/scitranslmed.adh1892

DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell–mediated antitumor immunity | Science Translational Medicine

⑦曲妥珠单抗生物类似药上市申请已获得批准；同时申请适应症外推，拟定适应症为：HER2阳性早期乳腺癌、HER2阳性转移性乳腺癌、HER2阳性转移性胃癌

⑧PD-1抑制剂多塔利单抗(Dostarlimab)用于原发性晚期或复发性子宫内膜癌的Ⅲ期临床RUBY达到总生存期（OS）的主要终点

⑨高选择性内皮素A（ETA）受体抑制剂Atrasentan用于IgA肾病的III期ALIGN研究达到主要终点

⑩PD-L1抗体恩沃利单抗获FDA批准开展Ⅲ期临床，评估恩沃利单抗联合仑伐替尼对比铂类用于错配修复完整（pMMR）晚期或复发性子宫内膜癌患者的有效性与安全性

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