柳叶刀重磅综述：CAR-T细胞靶向自身反应性B细胞的研究进展

关键词

CAR-T细胞 达雷妥尤单抗 2型糖尿病 登革热疫苗 耐药性 脊髓灰质炎病毒疫苗 依拉环素 CAR-T 度普利尤单抗

今日行业热点

①The Lancet：CAR T-cell therapy in autoimmune diseases

综述：CAR-T细胞靶向自身反应性B细胞的研究进展

DOI: 10.1016/S0140-6736(23)01126-1

②The Lancet Haematology：Minimal residual disease response-adapted therapy in newly diagnosed multiple myeloma (MASTER): final report of the multicentre, single-arm, phase 2 trial

临床试验：达雷妥尤单抗联合卡非佐米、来那度胺、地塞米松（Dara-KRd）用于新诊断多发性骨髓瘤患者的MASTER试验的最终分析结果

DOI: 10.1016/S2352-3026(23)00236-3

③The Lancet Diabetes and Endocrinology：Mechanisms of weight loss-induced remission in people with prediabetes: a post-hoc analysis of the randomised, controlled, multicentre Prediabetes Lifestyle Intervention Study (PLIS)

临床研究：减重诱导2型糖尿病前期患者缓解的机制：一项随机、对照、多中心糖尿病前期生活方式干预研究(PLIS)的事后分析

DOI: 10.1016/S2213-8587(23)00235-8

④The Lancet Infectious Diseases：Safety and durable immunogenicity of the TV005 tetravalent dengue vaccine, across serotypes and age groups, in dengue-endemic Bangladesh: a randomised, controlled trial

TV005四价登革热疫苗在登革热流行血清型和年龄组的安全性和持久免疫原性：一项随机对照试验

DOI: 10.1016/S1473-3099(23)00520-0

⑤The Lancet Infectious Diseases：Effectiveness of long-lasting insecticidal nets with pyriproxyfen–pyrethroid, chlorfenapyr–pyrethroid, or piperonyl butoxide–pyrethroid versus pyrethroid only against malaria in Tanzania: final-year results of a four-arm, single-blind, cluster-randomised trial

撒哈拉以南非洲杀虫剂混合物对拟除虫菊酯耐药性的有效性和耐久性：一项四臂、单盲、集群随机试验的最后一年结果

DOI: 10.1016/S1473-3099(23)00420-6

⑥The Lancet Microbe：Persistence of immunity following a single dose of inactivated poliovirus vaccine: a phase 4, open label, non-randomised clinical trial

单剂灭活脊髓灰质炎病毒疫苗后免疫力的持续性：一项Ⅳ期、开放标签、非随机临床试验

DOI: 10.1016/S2666-5247(23)00215-X

⑦全球首个氟环素类抗菌药物依拉环素用于复杂性腹腔内感染（cIAI）的新药上市许可申请（NDA）在中国台湾获批上市

⑧靶向Nectin-4 ADC创新药9MW2821与PD-1抑制剂联合用于局部晚期或转移性尿路上皮癌的Ib/II期临床试验完成首例患者给药

⑨IL-4/IL-13抑制剂度普利尤单抗（Dupixent）的补充生物制剂许可申请（sBLA）获FDA授予优先审评资格，用于1至11岁嗜酸性粒细胞性食管炎（EoE）

⑩BCMA/CD19双靶点自体CAR-T候选产品GC012F针对高危多发性骨髓瘤新确诊患者的最新临床数据积极，严格完全缓解率高达100%

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