国产首款DGKζ抑制剂获批临床；仑卡奈单抗在日本获批上市

关键词

病毒组 肿瘤免疫 免疫检查点 微生物群 真菌组 肿瘤微环境 干扰素基因刺激因子 贝伐珠单抗 纳武利尤单抗 仑卡奈单抗

今日行业热点

①Cell：Host traits shape virome composition and virus transmission in wild small mammals

宿主的性状影响野生小型哺乳动物病毒组的组成和病毒传播

DOI: 10.1016/j.cell.2023.08.029

②Cancer Cell：ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome

ZNF683标志着CD8+ T细胞群与Richter综合征(RS)抗PD-1治疗后的抗肿瘤免疫相关

DOI: 10.1016/j.ccell.2023.08.013

③Cancer Cell：Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I

通过微生物群介导的HLA I类上调使癌细胞对免疫检查点抑制剂敏感

DOI: 10.1016/j.ccell.2023.08.014

④Cancer Cell：The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

肿瘤内真菌组通过髓源性抑制细胞促进肺癌进展

DOI: 10.1016/j.ccell.2023.08.012

⑤Cell Chemical Biology：Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy

靶向甲基转移酶 3 (methyltransferase-like 3, METTL3)重编程肿瘤微环境以改善癌症免疫治疗

DOI: 10.1016/j.chembiol.2023.09.001

⑥Trends in Microbiology：STING negatively regulates antifungal immunity

干扰素基因刺激因子(stimulator of interferon genes, STING)负性调节抗真菌免疫

DOI: 10.1016/j.tim.2023.09.003

⑦选择性脂肪酸合成酶（FASN）口服小分子抑制剂ASC40联合贝伐珠单抗用于复发性胶质母细胞瘤（rGBM）患者的III期注册临床试验完成120例患者入组

⑧纳武利尤单抗联合化疗用于非转移性非小细胞肺癌的III期研究CheckMate -77T达到了盲态独立中心评估（BICR）的主要终点

⑨DGKζ抑制剂BGB-30813片的临床试验申请获得默认许可，拟开发用于晚期或转移性实体瘤

⑩仑卡奈单抗（Lecanemab）在日本获批上市，用于延缓阿尔茨海默病（AD）引起的轻度认知障碍（MCI）和轻度痴呆症的进展

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