睡眠和麻醉时脑电图指标与术前MoCA评分的相关性：一项初步研究

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睡眠和麻醉时脑电图指标与术前MoCA评分的相关性：一项初步研究

01 前言

术前认知功能障碍会增加术后并发症的风险。脑电图（EEG）可以提供有关认知易感性的信息。睡眠脑电图（EEGsleep）与术中脑电图（EEGintoraop）在认知风险分层中的可行性和临床相关性仍有待探索。本试验对睡眠脑电图和术中脑电图与术前认知障碍的相关性进行了研究。 

02 方法

纳入27例患者（平均63岁[53.5,70.0]），在丙泊酚全身麻醉前1天进行蒙特利尔认知评估量表（MoCA）评估和睡眠脑电图采集，并从深度麻醉监测仪获得术中脑电图。特别探讨了睡眠纺锤波和术中睡眠的α波段功率。

03 结果

共有11例（41%）患者的MoCA评分<25分。与正常MoCA评分的患者相比，这些患者的睡眠纺锤波功率明显较低（25比40 μv2 /Hz，P = 0.035），术中α波段功率较弱（85比150 μv2 /Hz，P = .001）。睡眠纺锤波与术中α波段功率之间呈显著正相关（r = 0.544，P =0 .003）。

04 结论

术前认知功能障碍似乎可通过睡眠脑电图和术中脑电图检测到。术前睡眠脑电图评估围手术期认知风险是可行的，但还需要更多的数据来证明其较术中脑电图的优势。

原始文献来源：

Cyril Touchard, Pauline Guimard, Karim Guessous,et al.Association of sleep and anaesthesia EEG biomarkers with preoperative MoCA score: A pilot study［J］.Acta Anaesthesiol Scand. 2023;1–8.    

英文原文：

Association of sleep and anaesthesia EEG biomarkers with preoperative MoCA score: A pilot study

Introduction: Preoperative cognitive impairments increase the risk of postoperative complications. The electroencephalogram (EEG) could provide information on cognitive vulnerability. The feasibility and clinical relevance of sleep EEG (EEGsleep) compared to intraoperative EEG (EEGintraop) in cognitive risk stratification remains to be explored. We investigated similarities between EEGsleep and EEGintraop vis-a-vis preoperative cognitive impairments.     Methods:  Pilot study including 27 patients (63 year old [53.5, 70.0]) to whom Montreal cognitive assessment (MoCA) and EEGsleep were administered 1 day before a propofol-based general anaesthesia, in addition to EEGintraop acquisition from depth of-anaesthesia monitors. Sleep spindles on EEGsleep and intraoperative alpha-band power on EEGintraop were particularly explored.     Results:  In total, 11 (41%) patients had a MoCA <25 points. These patients had a significantly lower sleep spindle power on EEGsleep (25 vs. 40 μv2 /Hz, p = .035) and had a weaker intraoperative alpha-band power on EEGintraop (85 vs. 150 μv2 /Hz, p = .001) compared to patients with normal MoCA. Correlation between sleep spindle and intraoperative alpha-band power was positive and significant (r = 0.544, p = .003).    

Conclusions: Preoperative cognitive impairment appears to be detectable by both EEGsleep and EEGintraop. Preoperative sleep EEG to assess perioperative cognitive risk is feasible but more data are needed to demonstrate its benefit compared to intraoperative EEG.

编辑：MiSuper.米超

校对：Michel.米萱

米勒之声编辑部 米勒之声，用心相伴

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