14种癌症模型优缺点

医药研究，尤其是药物临床前研究需要选择合适模型。但是，所有模型都不完美，又有其特定优势。根据优缺点和研究目的，选择合适的模型至关重要。

小鼠模型

人鼠模型

低等生物模型

3D培养物模型

参考资料

Tanner, K., and Gottesman, M.M. (2015). Beyond 3D culture models of cancer. Sci. Transl. Med. 7, 283ps9 Kreso, A., and Dick, J.E. (2014). Evolution of the cancer stem cell model. Cell Stem Cell 14, 275–291. Perez-Guijarro, E., Yang, H.H., Araya, R.E., El Meskini, R., Michael, H.T., Vodnala, S.K., Marie, K.L., Smith, C., Chin, S., Lam, K.C., et al. (2020). Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy. Nat. Med. 26, 781–791. Cogels, M.M., Rouas, R., Ghanem, G.E., Martinive, P., Awada, A., Van Gestel, D., and Krayem, M. (2021). Humanized Mice as a Valuable PreClinical Model for Cancer Immunotherapy Research. Front. Oncol. 11, 784947. Faugeroux, V., Pailler, E., Oulhen, M., Deas, O., Brulle-Soumare, L., Hervieu, C., Marty, V., Alexandrova, K., Andree, K.C., Stoecklein, N.H., et al. (2020). Genetic characterization of a unique neuroendocrine transdifferentiation prostate circulating tumor cell-derived eXplant model. Nat. Commun. 11, 1884. Patton, E.E., Zon, L.I., and Langenau, D.M. (2021). Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat. Rev. Drug Discov. 20, 611–628 Sontheimer-Phelps, A., Hassell, B.A., and Ingber, D.E. (2019). Modelling cancer in microfluidic human organs-on-chips. Nat. Rev. Cancer 19, 65–81.

来源： 闲谈 Immunology

2023-05-12

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