在全身麻醉诱导期间为避免患者呛咳和血流动力学波动的舒芬太尼推荐剂量

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在全身麻醉诱导期间为避免患者呛咳和血流动力学波动的舒芬太尼推荐剂量

贵州医科大    麻醉与心脏电生理课题组

翻译：严旭   编辑：柏雪   审校：曹莹

背景：舒芬太尼引起的咳嗽（SIC）是麻醉诱导过程中常见的并发症。我们通过一项临床试验，分析了避免呛咳、血流动力学波动和不良反应的有效剂量(ED)ED50和ED95，探索了在全身麻醉期间有效避免咳嗽的舒芬太尼剂量。

方法：136名患者（ASA I-II）根据舒芬太尼剂量随机分配到以下组：I组:0.1ug/kg；II组:0.3ug/kg；III组:0.5ug/kg；或IV组:1.0ug/kg。记录并分析了注射舒芬太尼后1分钟内咳嗽、头晕、恐慌和胸闷的次数，以及插管后5分钟患者的心率（HR）和血压。咳嗽评估如下，无:0次/分钟；轻度:1至2次/分钟；中度:3至4次/分钟；严重:5次/分钟或更多。

结果：在全身麻醉诱导期间，静脉注射舒芬太尼引起的咳嗽发生率ED50和ED95分别为0.332ug/kg和1.423ug/kg。I组的咳嗽率比其他组低。头晕、恐慌、胸闷、高血压、心动过缓和心动过速的发生率没有显著差异。

结论：全身麻醉诱导期间推荐的舒芬太尼剂量为0.1ug/kg。

原始文献来源：Ping Chen , Ping Zeng , Yuan Gong ,Recommended dose of sufentanil during induction of general anesthesia to avoid coughing and drastic hemodynamic fluctuations in patients undergoing surgery[J],J Int Med Res. 2021 Mar;49(3):300060521996143.

doi: 10.1177/0300060521996143.

英文原文：

Recommended dose of sufentanil during induction of general anesthesia to avoid coughing and drastic hemodynamic fluctuations in patients undergoing surgery

Abstract

Background: Sufentanil-induced cough (SIC) is a common complication during anesthesia induction. We explored the recommended sufentanil dose that effectively avoids cough during general anesthesia using a clinical trial to analyze the effective dose (ED)50 and ED95 of sufentanil that avoids cough, hemodynamic fluctuations, and adverse reactions.

Methods: On the basis of sufentanil dose, 136 patients (ASA class I-II) were randomly allocated into the following groups: I, 0.1 μg/kg; II, 0.3 μg/kg; III, 0.5 μg/kg; or IV, 1.0 μg/kg. The number of coughing incidents, dizziness, panic, and chest tightness within 1 minute after sufentanil injection, and the patient's heart rate (HR) and blood pressure 5 minutes after intubation were recorded and analyzed. Cough was assessed as follows: none, 0 times; mild, 1 to 2 times/minute; moderate, 3 to 4 times/minute; and severe, 5 times/minute or more.

Results: The ED50 and ED95 of cough incidence induced by intravenous sufentanil in patients during general anesthesia induction was 0.332 μg/kg and 1.423 μg/kg, respectively. The cough rate in group I was lower than the other groups. The incidence of dizziness, panic, chest tightness, hypertension, bradycardia, and tachycardia were not significantly different.

Conclusions: The recommended sufentanil dose during general anesthesia induction is 0.1 μg/kg.

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文中所涉及药物使用、疾病诊疗等内容仅供医学专业人士参考。

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编辑：Michel.米萱

校对：MiLu.米鹭

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