PCSK9单抗托莱西单抗用于高胆固醇血症的Ⅲ期研究成果显著

关键词

CD8+ 肿瘤免疫 APOE 阿尔茨海默病  CDK4/6 糖基化 阿得贝利单抗 托莱西单抗 全人源单克隆抗体

今日行业热点

①Cancer Cell：A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity

发现：一个独特的免疫刺激性1型传统树突状细胞(cDC1)亚群可增强肿瘤中CD8+ T细胞的反应，从而获得保护性抗肿瘤免疫

DOI: 10.1016/j.ccell.2023.06.008

②Trendsin Neurosciences：Genetics of SLE: mechanistic insights from monogenic disease and disease-associated variants

综述：APOE ε4对衰老的大脑的影响——不止于阿尔茨海默病

DOI: 10.1016/j.tins.2023.06.003

③Cell Reports Medicine ：Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

联合靶向RANK通路在管腔型乳腺癌（LBC）中对 CDK4/6 抑制剂的获得性耐药

DOI: 10.1016/j.xcrm.2023.101120

④Trends in Immunology：MAdCAM-1: a newly identified microbial 'gut check' for T cells

聚焦：MAdCAM-1，一种新发现的针对T细胞的微生物“肠道检查”

DOI: 10.1016/j.it.2023.06.007

⑤Trends in Cancer：Perivascular niches: critical hubs in cancer evolution

综述：血管周围生态位是癌症进化的关键枢纽

10.1016/j.trecan.2023.06.010

⑥Cell Chemical Biology：Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation

趋化因子与P-选择素糖蛋白配体-1 (PSGL-1)的结合受O-糖基化和酪氨酸硫酸化(sTyr)控制

DOI: 10.1016/j.chembiol.2023.06.013

⑦PD-L1单抗阿得贝利单抗注射液获国家药监局临床试验默示许可，拟联合靶向HER3的抗体偶联药物（ADC）SHR-A2009用于晚期实体瘤

⑧PCSK9单抗托莱西单抗（IBI306）用于中国高胆固醇血症患者的Ⅲ期CREDIT-4研究成果见刊，结果积极

⑨创新型靶向肿瘤细胞表面抗原 B7-H3的抗体偶联药物（ADC）7MW3711获NMPA批准针对晚期恶性实体瘤患者开展临床试验

⑩靶向CTLA-4的IgG1类全人源单克隆抗体候选药物BAT4706联合PD-1单抗BAT1308用于晚期实体瘤的临床试验申请获得批准

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