【罂粟摘要】舒芬太尼结合丙泊酚用于全凭静脉麻醉在根治性乳房切除术中的临床价值

舒芬太尼结合丙泊酚用于全凭静脉麻醉在根治性乳房切除术中的临床价值

贵州医科大学    麻醉与心脏电生理课题组

翻译 ：严旭    编辑 ：严旭   审校 ：曹莹

目的：研究舒芬太尼结合丙泊酚用于全凭静脉麻醉（TIVA）在根治性乳房切除术中的临床价值。

方法：回顾性分析2020年2月至2021年2月在我们医院接受乳腺癌根治性乳房切除术的120名患者的数据，并随机分配给实验组（EXG）（n = 60）和对照组（COG）（n = 60）。麻醉维持方案为0.01-0.03μg/（kg·min）的舒芬太尼+ 80-100 μg/（kg·min）的丙泊酚和3 μg/（kg·h）的舒芬太尼+ 80-100 μg/（kg·min）的丙泊酚。在EXG和COG之间比较了血流动力学指标、应激指数、术后疼痛评分和不良反应发生率。

结果：气管插管（T2）和深层组织分离（T3）、气管拔管（T4）和手术结束（T5）后的心率（HR）和平均动脉压（MAP）在EXG中明显低于COG（P < 0.001）。EXG在手术后1小时（T6）、6小时（T7）和12小时（T8）的压力指数和术后疼痛评分低于COG（P < 0.001）。与COG相比，EXG中头晕、头痛、瘙痒和出现躁动的发生率较低（P<0.05）。

结论：舒芬太尼与丙泊酚结合用于全凭静脉麻醉，可以稳定根治性乳房切除术的患者的术中血流动力学指数，缓解围手术期应激反应，并减少疼痛感知。因此，这种麻醉方法是安全的，值得临床推广。

原始文献:Lingyan Qu , Xiaoqing Wu ,Clinical Value of Total Intravenous Anesthesia with Sufentanil and Propofol in Radical Mastectomy[J].is Markers. 2022 Aug 5;2022:7294358.doi:10.1155/2022/7294358. eCollection 2022.

英文原文:Clinical Value of Total Intravenous Anesthesia with Sufentanil and Propofol in Radical Mastectomy

Abstract

Objective: To investigate the clinical value of sufentanil combined with propofol for total intravenous anesthesia (TIVA) in radical mastectomy.

Methods: The data of 120 patients undergoing radical mastectomy of breast cancer in our hospital from February 2020 to February 2021 were retrospectively analyzed, and they were randomly assigned to the experimental group (EXG) (n = 60) and the control group (COG) (n = 60). The anesthesia maintenance scheme was 0.01-0.03 μg/(kg·min) of sufentanil + 80-100 μg/(kg·min) of propofol in EXG and 3 μg/(kg·h) of fentanyl + 80-100 μg/(kg·min) of propofol in COG. The hemodynamic indices, stress indexes, postoperative pain scores, and incidence of adverse reactions were compared between EXG and COG.

Results: The heart rates (HR) and mean arterial pressure (MAP) after tracheal intubation (T2) and at separation of deep tissues (T3), tracheal extubation (T4), and the end of surgery (T5) were markedly lower in EXG than in COG (P < and 12 h (T8) after surgery were lower in EXG than in COG (P < 0.001). The was lower compared with that in COG (P < 0.05).

Conclusion: Sufentanil combined with propofol for TIVA can stabilize intraoperative hemodynamic indices of patients undergoing radical mastectomy, alleviate perioperative stress response, and reduce pain perception. Therefore, this anesthesia method is safe and merits clinical promotion.

打赏