癌症神经科学：领域现状、新兴方向

2023-05-04 13:48

神经系统控制着个体发育和肿瘤学。神经系统在发育过程中调节器官形成，维持体内平衡，并在一生中促进可塑性，在癌症的调节中也发挥着相似的作用。

SCI 2 May 2023

Cancer neuroscience: State of the field, emerging directions

(Cell, IF: 66.850)

Winkler F, Venkatesh HS, Amit M, Batchelor T, Demir IE, Deneen B, Gutmann DH, Hervey-Jumper S, Kuner T, Mabbott D, Platten M, Rolls A, Sloan EK, Wang TC, Wick W, Venkataramani V, Monje M. Cancer neuroscience: State of the field, emerging directions. Cell. 2023 Apr 13;186(8):1689-1707. doi: 10.1016/j.cell.2023.02.002. PMID: 37059069; PMCID: PMC10107403.

Correspondence: frank.winkler@med.uni-heidelberg.de(F.W.), varun.venkataramani@med.uni-heidelberg.de (V.V.), mmonje@stanford.edu(M.M.)

Abstract

The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.

神经系统控制着个体发育和肿瘤学。神经系统在发育过程中调节器官形成，维持体内平衡，并在一生中促进可塑性，在癌症的调节中也发挥着相似的作用。基础性发现阐明了神经元和癌症细胞之间直接的旁分泌和电化学信号传递，以及在多种恶性肿瘤的肿瘤微环境中通过神经对免疫系统和基质细胞的影响而间接相互作用。神经系统与肿瘤的相互作用可以调节肿瘤的产生、生长、侵袭和转移扩散、治疗耐药、促肿瘤炎症的刺激以及抗癌免疫功能的损害。癌症神经科学的进展可能会成为癌症治疗的重要新支柱。