[罂粟摘要]深呼吸可减轻异丙酚引起的疼痛：一项前瞻性、随机、单盲研究

深呼吸可减轻异丙酚引起的疼痛：一项前瞻性、随机、单盲研究

贵州医科大学麻醉与心脏电生理课题组

翻译 :  文春雷 

编辑 :  严旭 

审校 :  曹莹

目的 ：异丙酚常用于麻醉诱导；然而，异丙酚的缺点是它带来的的注射痛。本研究旨在评估深呼吸是否能减轻异丙酚注射痛。  

方法：这项前瞻性、单盲、随机对照研究包括200名计划在全身麻醉下接受择期手术的患者，并将他们随机平均分为D组和C组。观察者给予患者止痛方式不是盲法，但每个患者采用盲法。D组患者在异丙酚全身麻醉诱导过程中重复深呼吸。C组患者按常规呼吸。采用视觉模拟量表（VAS）评估异丙酚注射性疼痛的强度。此外，我们记录了患者的疼痛表达，包括表情和手部退缩反应，以及复苏室（PACU）使用VAS测量的回忆性疼痛。

结果：与C组患者相比，D组患者异丙酚注射痛VAS评分明显减少（20[四分位（IQR）：0-48]vs.37[IQR 9-65]，P=0.017)，PACU回忆性疼痛（16 [IQR 0-32]vs.26[IQR 0.5-51]，P=0.031）。此外，D组（18%）的疼痛表情发生率明显低于C组（45%）（P<0.001）。回忆性疼痛和缩手反应发生率没有明显的差异。

结论：深呼吸可能是一种简单、安全、廉价的减轻异丙酚注射痛的方法。

原始文献来源 ：  

Katsuaki Tanaka， Yuko Yoshizumi，Taku Hamada,et al.Deep breathing alleviates propofol‑induced pain: a prospective, randomized, single‑blind study.[J].Journal of Anesthesia,2023,31（1）:97–103.

英文原文

Deep breathing alleviates propofol‑induced pain: a prospective, 

randomized, single‑blind study

Purpose: Propofol is commonly used to induce general anesthesia; however, the pain caused during propofol injection is a disadvantage. This study aimed to assess whether deep breathing attenuates propofol injection pain.

Methods: This prospective, single-blind, randomized controlled study included 200 patients who were scheduled to undergo elective surgery under general anesthesia and randomly and equally divided them into group D and group C. The observers were not blinded to the pain-relieving modality, but each patient was blinded. Group D patients were requested to repeatedly take deep breaths throughout general anesthesia induction with propofol. Group C patients were requested to breathe in the usual manner. The intensity of propofol injection pain was evaluated using the visual analog scale (VAS). Furthermore, we recorded the patients’ pain expressions, including grimace or hand-withdrawal, and the recalled pain measured using a VAS in the post-anesthetic care units (PACU).

Results: Compared with patients in group C, those in group D showed signifcantly reduced VAS scores for propofol injection pain (20 [interquartile range (IQR): 0–48] vs. 37 [IQR 9–65], P=0.017) and recalled pain in the PACU (16 [IQR 0–32] vs. 26 [IQR 0.5–51], P=0.031). Further, the grimace incidence was signifcantly lower in group D (18%) than in group C (45%) (P<0.001). There was no signifcant diference in the incidence of pain at induction, recalled pain, or hand-withdrawal.

Conclusions: Deep breathing could be an easy, safe, and inexpensive method for reducing pain during propofol injection.

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