「小普日报」2023年4月24日热点速递

关键词

免疫检查点 单抗 合胞病毒 系统性红斑狼疮 DNA  

#今日行业热点#

①Lancet：Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial

临床试验：免疫检查点抑制剂派姆单抗联合吉西他滨和顺铂用于晚期胆道癌患者的Ⅲ期随机、对照试验

DOI :10.1016/S0140-6736(23)00727-4

②Lancet：The link between respiratory syncytial virus infection during infancy and asthma during childhood

婴儿期呼吸道合胞病毒感染与儿童期哮喘之间的联系

DOI :10.1016/S0140-6736(23)00672-4

③Trends in Cancer：Bone marrow microenvironment: roles and therapeutic implications in obesity-associated cancer

综述：肥胖期间BMME（骨髓微环境）对癌症的影响及其在应对癌症策略方面的意义

DOI :10.1016/j.trecan.2023.03.007

④Nature Communications：DNA-binding mechanism and evolution of replication protein A

同源核苷酸复制蛋白A（RPA）DNA结合机制及其进化

DOI :10.1038/s41467-023-38048-w

⑤Clinical Immunology：Serum proteome and metabolome uncover novel biomarkers for the assessment of disease activity and diagnosing of systemic lupus erythematosus

血清蛋白质组学和代谢组学中发现用于评估自身免疫性疾病系统性红斑狼疮（SLE）的新生物标记物

DOI :10.1016/j.clim.2023.109330

⑥Clinical Immunology：Manufacturing regulatory T cells for adoptive cell therapy in immune diseases: A critical appraisal

综述：应对免疫疾病的巨噬细胞调节性T细胞(Tregs)及其用于临床前和临床试验的方法与结果

DOI :10.1016/j.clim.2023.109328 ⑦全球唯一用于IgA肾病的靶向肠道的黏膜免疫调节剂口服靶向布地奈德迟释胶囊在海南获批落地，将应用于临床使用

⑧甲苯磺酸ZG2001片用于KRAS突变的晚期实体瘤临床试验申请获美FDA批准

⑨创新生物药BL-M11D1（CD33-ADC）获国家药监局批准开展用于复发或难治性急性髓系白血病的临床试验

⑩中国临床肿瘤学会（CSCO）2023CSCO指南发布，注射用紫杉醇聚合物胶束获推入选，用于非鳞癌非小细胞肺癌（NSCLC）

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