不断演变中的肿瘤微环境：从癌症发生到转移生长

2023-03-25 09:19

癌症代表了复杂的生态系统，包括肿瘤细胞和大量非癌细胞，嵌入改变的细胞外基质中。

SCI 24 March 2023

The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

（IF: CANCER CELL, 38.585）

de Visser KE, Joyce JA. The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell. 2023 Mar 13;41(3):374-403.

Correspondence: k.d.visser@nki.nl (K.E.d.V.), johanna.joyce@unil.ch (J.A.J.)

Cancers represent complex ecosystems comprising tumor cells and a multitude of non-cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment (TME) includes diverse immune cell types, cancer-associated fibroblasts, endothelial cells, pericytes, and various additional tissue-resident cell types. These host cells were once considered bystanders of tumorigenesis but are now known to play critical roles in the pathogenesis of cancer. The cellular composition and functional state of the TME can differ extensively depending on the organ in which the tumor arises, the intrinsic features of cancer cells, the tumor stage, and patient characteristics. Here, we review the importance of the TME in each stage of cancer progression, from tumor initiation, progression, invasion, and intravasation to metastatic dissemination and outgrowth. Understanding the complex interplay between tumor cell-intrinsic, cell-extrinsic, and systemic mediators of disease progression is critical for the rational development of effective anti-cancer treatments.

癌症代表了复杂的生态系统，包括肿瘤细胞和大量非癌细胞，嵌入改变的细胞外基质中。肿瘤微环境（TME）包括多种免疫细胞类型、癌症相关成纤维细胞、内皮细胞、周细胞和各种其他组织-驻留细胞类型。这些宿主细胞曾被认为是肿瘤发生的旁观者，但现在已知它们在癌症的发病机制中发挥着关键作用。TME的细胞组成和功能状态可能会因肿瘤发生的器官、癌症细胞的固有特征、肿瘤分期和患者特征而大不相同。此处，我们回顾了TME在癌症进展的各个阶段的重要性，从肿瘤的发生、进展、侵袭、渗透到转移性播散和生长。了解肿瘤细胞内在、细胞外在和疾病进展的系统介质之间的复杂相互作用，对于合理开发有效的抗癌治疗至关重要。