「小普日报」2023年2月23日热点速递

关键词

癌基因 抗体 靶点 单克隆抗体  AI 新冠

今日行业热点

①Nature Reviews Clinical Oncology：Rare molecular subtypes of lung cancer

罕见癌基因驱动的肺癌分子亚型

DOI :10.1038/s41571-023-00733-6

②Nature Cancer：Advances in antibody-based therapy in oncology

综述：肿瘤学中基于抗体的治疗的进展——新近工程抗体治疗候选类别、分子结构和作用机制

DOI :10.1038/s43018-023-00516-z

③Matrix Biology：Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides

靶向LAYN可抑制透明质酸寡糖诱导的结直肠癌转移和肿瘤相关巨噬细胞浸润 DOI :10.1016/j.matbio.2023.02.005

④Cancer Immunology Research：Reverse translation identifies the synergistic role of immune checkpoint blockade and IL-15 to enhance immunotherapy of ovarian cancer

PD-1/PD-L1阻断联合IL-15信号通路可能克服卵巢癌对细胞因子治疗的耐药性

DOI :10.1158/2326-6066.CIR-22-0600

⑤Allergy：Hinge region modification for the engineering of antibody function

用于抗体功能工程的铰链区修饰

DOI :10.1111/all.15684

⑥Kidney International：Identification of proteinase 3 autoreactive CD4+T cells and their T-cell receptor repertoires in anti-neutrophil cytoplasmic antibodies associated vasculitis

PR3-ANCA 相关性血管炎（PR3-AAV）患者的PR3特异性CD4+T细胞反应和自身反应性T细胞的特征

DOI :10.1016/j.kint.2023.01.023

⑦靶向补体因子C5的全人源IgG4单克隆抗体靶向药C5单抗获美国FDA优先审评治疗CHAPLE疾病

⑧辉瑞二价呼吸道合胞病毒(RSV)候选疫苗生物制品许可申请获得FDA的优先审查

⑨由Insilico Medicine AI筛选的一款靶向主蛋白酶（3CLpro）的高选择性小分子抑制剂临床试验申请获批

⑩美国FDA出台法规草案：允许植物奶标注为“奶”