我们提出了一个多学科门诊癌症筛查一站式方法的概念研究证明。我们成功地在早期发现了癌症,这有可能降低发病率和死亡率,并节省大量成本。
SCI
16 February 2023
Data From a One-Stop-Shop Comprehensive Cancer Screening Center
(J Clin Oncol, IF: 50.717)
Bernstein E, Lev-Ari S, Shapira S, et al. Data From a One-Stop-Shop Comprehensive Cancer Screening Center. J Clin Oncol 2023:JCO2200938.
PURPOSE 目的
Cancer is the second leading cause of death globally. However, by implementing evidence-based prevention strategies, 30%-50% of cancers can be detected early with improved outcomes. At the integrated cancer prevention center (ICPC), we aimed to increase early detection by screening for multiple cancers during one visit.
癌症是全球第二大死亡原因。然而,通过实施循证预防策略,30%-50%的癌症可以早期发现,并改善预后。在综合癌症预防中心(ICPC),我们的目标是通过在一次访问中筛查多种癌症来提高早期发现。
METHODS 方法
Self-referred asymptomatic individuals, age 20-80 years, were included prospectively. Clinical, laboratory, and epidemiological data were obtained by multiple specialists, and further testing was obtained based on symptoms, family history, individual risk factors, and abnormalities identified during the visit. Follow-up recommendations and diagnoses were given as appropriate.
前瞻性地纳入自我对照的无症状个体,年龄20-80岁。由多位专家获得临床、实验室和流行病学数据,并根据就诊期间发现的症状、家族史、个体危险因素和异常情况进行进一步检测。适当地给予随访建议和诊断。
RESULTS 结果
Between January 1, 2006, and December 31, 2019, 8,618 men and 8,486 women, average age 47.11 +/- 11.71 years, were screened. Of 259 cancers detected through the ICPC, 49 (19.8%) were stage 0, 113 (45.6%) stage I, 30 (12.1%) stage II, 25 (10.1%) stage III, and 31(12.5%) stage IV. Seventeen cancers were missed, six of which were within the scope of the ICPC. Compared with the Israeli registry, at the ICPC, less cancers were diagnosed at a metastatic stage for breast (none v 3.7%), lung (6.7% v 11.4%), colon (20.0% v 46.2%), prostate (5.6% v 10.5%), and cervical/uterine (none v 8.5%) cancers. When compared with the average stage of detection in the United States, detection was earlier for breast, lung, prostate, and female reproductive cancers. Patient satisfaction rate was 8.35 +/- 1.85 (scale 1-10).
2006年1月1日至2019年12月31日,8,618名男性和8,486名女性接受了筛查,平均年龄为47.11±11.71岁。在通过ICPC检测到的259例癌症中,49例(19.8%)为0期,113例(45.6%)为I期,30例(12.1%)为II期,25例(10.1%)为III期,31例(12.5%)为IV期。17例癌症被遗漏,其中6例在ICPC范围内。与以色列登记处相比,在ICPC中,乳腺癌(无癌vs 3.7%)、肺癌(6.7% vs 11.4%)、结肠癌(20.0% vs 46.2%)、前列腺癌(5.6% vs 10.5%)和宫颈癌/子宫癌(无癌vs 8.5%)的转移期癌症诊断较少。与美国的平均检出阶段相比,乳腺癌、肺癌、前列腺癌和女性生殖器官癌的检出较早。患者满意度为8.35 +/- 1.85(1-10量表)。
CONCLUSION 结论
We present a proof of concept study for a one-stop-shop approach to cancer screening in a multidisciplinary outpatient clinic. We successfully detected cancers at an early stage, which has the potential to reduce morbidity and mortality as well as offer substantial cost savings.
我们提出了一个多学科门诊癌症筛查一站式方法的概念研究证明。我们成功地在早期发现了癌症,这有可能降低发病率和死亡率,并节省大量成本。
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