【罂粟摘要】麻醉和麻醉技术对肺癌转移的影响：叙述性回顾

麻醉和麻醉技术对肺癌转移的影响：叙述性回顾

贵州医科大学    麻醉与心脏电生理课题组

翻译：柏雪  编辑：潘志军  审校：曹莹

目的：肿瘤复发和转移对癌症的死亡率和发病率至关重要。手术切除实体瘤是恶性肿瘤的常规治疗方法。然而，即使在接受根治性手术后，某些患者也会出现局部或远处转移，这可能导致治疗失败。麻醉和麻醉技术广泛应用于围手术期。新出现的证据表明，麻醉剂会影响肿瘤的复发和转移。因此，本综述总结了麻醉和麻醉技术对肿瘤复发和肺转移的影响。

方法：相关文献检索自以下数据库：Medline/PubMed、CNKI、万方。本研究共筛选和分析了 109 篇文章。

结果：（1）多种静脉麻醉药可能影响肿瘤转移或生长，但证据相互矛盾，临床资料尚无定论。(2)挥发性麻醉剂具有促炎作用，可能对癌细胞的存活有直接和间接的影响。(3)虽然相关临床资料有限，但强有力的证据表明局麻药对癌症复发具有保护作用。(4) 尚未确定麻醉方式对癌症患者有益，但目前临床研究推荐麻醉方式为复合使用。

结论：现有数据表明，麻醉和麻醉技术可能在抑制肿瘤进展和肺转移中发挥重要作用，加强了解将有助于选择最优麻醉方式以便于肿瘤管理并减少麻醉副作用。

原始文献来源：

Zhenghuan Song , Jing Tan. Effects of Anesthesia and Anesthetic T echniques on Metastasis of Lung Cancers: A Narrative Review. Cancer Management and Research 2022:14 189–204.

英文原文

Effects of Anesthesia and Anesthetic T echniques on Metastasis of Lung Cancers: A Narrative Review

Purpose: Tumor recurrence and metastasis are essential for the mortality and morbidity of cancer. Surgical resection of solid tumors is the conventional treatment approach for malignant tumors. However, even after undergoing radical surgery, certain patients develop local or distant metastasis, which may contribute to treatment failure. Anesthesia and anesthetic techniques are widely used in the perioperative period. Emerging evidence indicates that anesthetics influence tumor recurrence and metastasis. Therefore, the current review summarizes the effects of anesthesia and anesthetic techniques on tumor recurrence and lung metastasis.

Methods: Relevant literature was retrieved from the following databases: Medline/PubMed, CNKI and Wanfang. A total of 109 articles were selected and analyzed in this research.

Results: (1) A variety of intravenous anesthetics may affect metastasis or tumor growth, though the evidence is contradictory and inconsistent, and the clinical data are still inconclusive. (2) Volatile anesthetics have proinflammatory effects and may have direct and indirect effects on the survival of cancer cells. (3) Although the relevant clinical data are limited, there is strong evidence in vitro that local anesthetics have a protective effect on cancer recurrence. (4) No mode of anesthesia has been determined to be beneficial to patients with cancer, but clinical studies are currently recommended for anesthesia modality and composite use.

Conclusion: Available data suggest that anesthesia and anesthetic techniques might play an important role in tumor progression and lung metastasis, the understanding of which will help in designing more effective management of the tumor and attaining fewer side effects.

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