【衡道丨干货】WHO图注英⽂学习⼿帐 (卵巢子宫内膜样肿瘤篇)

衡道病理特邀撰稿作者翻译了WHO部分图⽚的图注，并用手帐的⽅式进行中英对照，且通过不同颜色的划线将晦涩难懂的英文单词与中⽂翻译同时标注，希望对专业英文的学习有所帮助。上一期分享了卵巢黏液性肿瘤，本期将带来卵巢子宫内膜样肿瘤。由于本篇目的以英文学习为主，篇幅有限，故未对各个疾病进行详细阐述。全部图片均来自WHO，若有不恰当之处，还请评论区指正。

WHO图注英文学习手帐

一、Endometrioid cystadenoma and adenofibroma   子宫内膜样囊腺瘤和腺纤维瘤  

Definition

Endometrioid cystadenomaand adenofibroma are benign epithelial tumours exhibiting endometrioid differentiation.

定义

子宫内膜样囊腺瘤和腺纤维瘤是良性上皮肿瘤，表现为子宫内膜样分化。

ICD-O coding

8380/0 Endometrioid cystadenoma NOS

8381/0 Endometrioid adenofibroma NOS

ICD-O编码

8380/0子宫内膜样囊腺瘤NOS

8381/0子宫内膜样腺纤维瘤NOS

Essential and desirable diagnostic criteria

Essential: cystadenoma: cyst lined by benign endometrioid epithelium without endometrial stroma; adenofibroma: widely spaced benign endometrioid glands associated with fibromatous stroma.

Desirable: endometriosis.

必须和理想的诊断标准

必须：囊腺瘤:囊肿衬覆良性子宫内膜样上皮，无子宫内膜间质;

腺纤维瘤:分布稀疏的良性子宫内膜样腺体伴纤维瘤间质。

理想：子宫内膜异位。

Fig. 1.36 Endometrioid adenofibroma. A Endometrioid glands are widely spaced within fibromatous stroma. B Bland endometrioid glands show focal squamous differentiation.

图1.36子宫内膜样腺纤维瘤。A子宫内膜样腺体广泛分布在纤维瘤性间质中。B良性子宫内膜样腺体显示局灶鳞状分化。

二、Endometrioid borderline tumour

子宫内膜样交界性肿瘤  

Definition

Endometrioid borderline tumour is an epithelial tumour composed of crowded endometrioid glands and lacking confluent or destructive invasion.

定义

子宫内膜样交界性肿瘤是一种由拥挤的子宫内膜样腺体组成的上皮性肿瘤，缺乏融合性或毁损性浸润。

ICD-O coding

8380/1 Endometrioid tumour, borderline

ICD-O编码

8380/1子宫内膜样肿瘤，交界性

Essential and desirable diagnostic criteria

Essential: adenofibromatous pattern: closely packed, crowded endometrioid glands varying in size, with irregular contours, in a vaguely lobular architecture surrounded by fibromatous stroma; intracystic pattern: simple papillae protruding into an endometriotic cyst; low to moderate nuclear atypia; non-confluent architecture; no destructive stromal invasion.

Desirable: associated endometriosis / endometriotic cyst.

必须和理想的诊断标准

必须:腺纤维瘤型:子宫内膜样腺体排列拥挤，大小不一，轮廓不规则，在模糊的小叶结构中，周围包绕纤维瘤性间质;

囊内型:简单的乳头突出到子宫内膜异位囊肿内;轻至中度核异型性;无融合性结构;无损毁性间质浸润。

理想：伴发子宫内膜异位症/子宫内膜异位症囊肿。

Fig. 1.37 Endometrioid borderline tumour. Proliferation of endometrioid glands (right) arising in an endometrioid adenofibroma (left).

图1.37子宫内膜样交界性肿瘤。子宫内膜样腺体增生(右)出现在子宫内膜样腺纤维瘤中(左)。

Fig. 1.38 Endometrioid borderline tumour. Proliferation of endometrioid glands with intracystic papillary growth embedded in a fibrous stroma.

图1.38子宫内膜样交界性肿瘤。纤维间质内子宫内膜样腺体增生伴囊内乳头状生长。

Fig. 1.39 Endometrioid borderline tumour. Proliferation of endometrial glands with features resembling atypical hyperplasia.

图1.39子宫内膜样交界性肿瘤。子宫内膜腺体增生，类似不典型增生。

Fig. 1.40 Endometrioid borderline tumour. Proliferation of endometrioid glands with extensive squamous metaplasia.

图1.40子宫内膜样交界性肿瘤。子宫内膜样腺体增生伴广泛鳞化。 

三、Endometrioid carcinoma of the ovary

卵巢的子宫内膜样癌  

Definition

Endometrioid carcinoma of the ovary is a carcinoma resembling endometrioid carcinoma of the uterine corpus.

定义

卵巢子宫内膜样癌是一种类似于子宫体子宫内膜样癌的癌。

ICD-O coding

8380/3 Endometrioid adenocarcinoma NOS

ICD-O编码

8380/3子宫内膜样癌NOS

Essential and desirable diagnostic criteria

Essential: a tumour with confluent or destructive stromal invasion by atypical endometrioid glands with variable solid component.

Desirable: squamous differentiation, associated endometriosis, or an endometrioid adenofibroma component.

必须和理想的诊断标准

必须:非典型子宫内膜样腺体具有不同程度实性成分，具有融合性或毁损性间质浸润。

理想:鳞状分化，相关的子宫内膜异位症，或子宫内膜样腺纤维瘤成分。

Fig. 1.41 Endometrioid carcinoma. The lining cells exhibit abundant cytoplasm and low nuclear atypia; squamous morules are present.

图1.41子宫内膜样癌。衬覆细胞胞质丰富，轻度核异型性；可见鳞状桑葚小体。

Fig. 1.42 Endometrioid carcinoma. A Confluent tubular/glandular growth without interveningstroma. B The lining cells exhibit abundant non-mucinous cytoplasm, with moderate atypia and prominent nucleoli.

图1.42子宫内膜样癌。融合管状/腺状生长，没有间质分隔。B衬覆细胞有丰富的非黏液性胞质，中度异型性，核仁突出。

Fig. 1.43 Endometrioid carcinoma. A Solid architecture (grade 3) showing geographical necrosis, which can cause confusion with tubo-ovarian high-grade serous or metastatic colorectal adenocarcinoma. B Solid growth with squamous differentiation and necrosis.

图1.43子宫内膜样癌。实体结构(3级)显示地图状坏死，可与输卵管-卵巢高级别浆液性或转移性结直肠腺癌混淆。B实性生长伴鳞化和坏死。

Fig. 1.44 Endometrioid carcinoma. Trabecular pattern resembling a sex cord-stromal tumour.

图1.44子宫内膜样癌。小梁状模式类似性索间质肿瘤。

Fig. 1.45 Endometrioid carcinoma. Trabecular pattern with focal gland formation reminiscent of sex cord-stromal tumour.

图1.45子宫内膜样癌。小梁状生长伴局灶腺体形成，类似性索间质肿瘤。

Fig. 1.46 Endometrioid carcinoma. A Corded and hyalinized pattern, as well as a spindled cell component. B Spindled cells are often seen in the corded and hyalinized pattern.

图1.46子宫内膜样癌。A条索状和透明变模式，以及伴有梭形细胞成分。B条索状和透明变样模式中常见梭形细胞成分。

Fig. 1.47 Endometrioid carcinoma. A The tumour exhibits a pronounced papillary architecture. B Papillary pattern, but the cytological atypia is less than in tubo-ovarian high-grade serous carcinoma.

图1.47子宫内膜样癌。肿瘤呈显著的乳头状结构。B乳头状模式，但细胞异型性小于输卵管-卵巢高级别浆液性癌。

Fig. 1.48 Endometrioid carcinoma. A Glandular pattern and secretory changes. B Endometrioid-type cells with subnuclearvacuolization, similar to day 16 secretory endometrium.

图1.48子宫内膜样癌。A腺样模式伴分泌改变。B子宫内膜样细胞伴核下空泡，类似于第16天分泌期宫内膜。

整理：南瓜子儿

审核：樊月

设计：鹏飞

编辑：雅芸

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