Nature neurosci—自私的本质：你选择自私？还是利他？BLA-PFC环路说了算！！

中文摘要

有利于自己利益而非另一个人利益的决定取决于环境和个人之间的关系。自私选择或有益于他人的选择背后的神经生物学机制尚不清楚。研究人员开发了一个双重选择的社会决策任务，在这个任务中，老鼠可以决定是否与其同类分享奖励。利他主义的选择偏好受熟悉度、性别、社会接触、饥饿、等级地位和情绪状态匹配的影响。光纤计记录和化学遗传学操作表明，基底外侧杏仁核（BLA）神经元参与了亲社会决策的建立。特别是，投射到前额叶皮层前缘（PL）区域的BLA神经元介导了利他选择偏好，而投射到BLA的PL神经元主导了决策的自私动机。这项研究提供了利他主义和自私选择的神经生物学模型，与社会决策功能障碍相关的病理相关。

英文摘要

Decisions that favor one's own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We developed a two-choice social decision-making task in which mice can decide whether to share a reward with their conspecifics. Preference for altruistic choices was modulated by familiarity, sex, social contact, hunger, hierarchical status and emotional state matching. Fiber photometry recordings and chemogenetic manipulations demonstrated that basolateral amygdala (BLA) neurons are involved in the establishment of prosocial decisions. In particular, BLA neurons projecting to the prelimbic (PL) region of the prefrontal cortex mediated the development of a preference for altruistic choices, whereas PL projections to the BLA modulated self-interest motives for decision-making. This provides a neurobiological model of altruistic and selfish choices with relevance to pathologies associated with dysfunctions in social decision-making.

参考文献：Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice.Nat Neurosci.2022 Nov;25(11):1505-1518. doi: 10.1038/s41593-022-01179-2. Epub 2022 Oct 24.

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