麻醉诱导中丙泊酚和罗库溴铵的注射疼痛和退缩反应对妇科腹腔镜手术术后疼痛的影响：一项前瞻性观察研究

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麻醉诱导中丙泊酚和罗库溴铵的注射疼痛和退缩反应对妇科腹腔镜手术术后疼痛的影响：一项前瞻性观察研究

贵州医科大学    麻醉与心脏电生理课题组

翻译：严旭  编辑：潘志军  审校：曹莹

引言：个人之间的疼痛体验可能有所不同。这项前瞻性队列研究旨在确定丙泊酚和罗库溴铵在麻醉诱导中的注射疼痛和退缩反应对妇科腹腔镜手术的术后疼痛的影响。    

方法：麻醉诱导共有100名年龄在19-60岁的患者接受了丙泊酚和罗库溴铵的注射。评估了丙泊酚注射疼痛（PIP）和罗库溴铵诱导的退缩反应（RIWM）的发生率、术后疼痛评分和阿片类药物总消耗量，并确定了PIP和RIWM与术后疼痛之间的关联。    

结果：患有丙泊酚注射疼痛或罗库溴铵诱导的退缩反应的患者术后疼痛的视觉模拟量表（VAS）和术后阿片类药物总消耗量明显高于没有PIP或RIWM的患者。PIP和RIWM、1小时的VAS、24小时的VAS、阿片类药物总消耗量之间的相关性显著且为弱正值（分别为r = 0.2。）   

结论：在麻醉诱导期间，PIP和RIWM的发生可能会预测术后疼痛的严重程度和阿片类药物的总消耗量，其中RIWM是一个比PIP更强的预测因素。  

原始文献来源：

Effect of injection pain and withdrawal movement of propofol and rocuronium in the induction of anesthesia on postoperative pain outcomes in gynaecologic laparoscopic surgery:a prospective observational study 2022 May 13. doi:10.11622/smedj.2022040.  Online ahead of print. PMID: 35546140  DOI: 10.11622/smedj.2022040

英文原文

Effect of injection pain and withdrawal movement of propofol and rocuronium in the induction of anesthesia on postoperative pain outcomes in gynaecologic laparoscopic surgery:a prospective observational study

ABSTRACT

INTRODUCTION：The pain experience among individuals may differ from each other. This prospective cohort study aimed to determine the impact of injection pain/withdrawal movement of propofol and rocuronium in the induction of anaesthesia on postoperative pain outcomes in gynaecologic laparoscopic surgery.

METHODS ：A total of 100 patients aged 19–60 years received propofol and rocuronium injections for the induction of anaesthesia. The incidence of propofol injection pain (PIP) and rocuronium-induced withdrawal movement (RIWM), postoperative pain scores and total opioid consumption were evaluated, and the associations between PIP/RIWM and postoperative pain outcomes were determined

RESULTS ：Visual analog scale (VAS) for pain after surgery and total opioid consumption after surgery in patients with PIP or RIWM were significantly higher than in patients without PIP or RIWM. The correlation between PIP and RIWM, VAS at 1 hour, VAS at 24 hours, total opioid consumption were significant and weakly positive (r = 0.249, r = 0.234, r = 0.22, r = 0.234, respectively). Compared with PIP, RIWM correlated more positively with pain score at 1 hour (r = 0.408 vs. r = 0.234, RIWM vs. PIP) and 24 hours (r = 0.398 vs r = 0.227, RIWM vs. PIP) and total opioid consumption after 48 hours (r = 0.457 vs. r = 0.234, RIWM vs. PIP).

CONCLUSION：During anaesthesia induction, the occurrence of PIP and RIWM may predict the severity of postoperative pain and total opioid consumption, with RIWM emerging as a stronger predictor than PIP. 

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编辑：MiLu.米鹭

校对：Michel.米萱

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