健康和疾病中的一氧化氮信号

2022-08-19 11:08

NO是心血管功能、代谢、神经传递、免疫等的关键调节因子，异常的NO信号是许多主要疾病的中心特征，包括心血管疾病、糖尿病和癌症。在这里，我们讨论了NO生物学的基础，强调了该领域的最新进展，包括增加NO生物活性的治疗和营养意义的新手段。

Nitric oxide signaling in health and disease（Nature IF: 42.778）

Lundberg JO, Weitzberg E. Nitric oxide signaling in health and disease. Cell 2022;185(16):2853-2878. DOI: 10.1016/j.cell.2022.06.010.

SUMMARY 概要

The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian cells and serves to regulate a multitude of physiological processes has continued to fascinate biologists for almost four decades. The biochemistry of NO is complex, and novel insights into the control of NO biosynthesis and mechanisms of signal transduction are continuously emerging. NO is a key regulator of cardiovascular function, metabolism, neurotransmission, immunity, and more, and aberrant NO signaling is a central feature of many major disorders including cardiovascular disease, diabetes, and cancer. Here, we discuss the basics of NO biology emphasizing recent advances in the field including novel means of increasing NO bioactivity with therapeutic and nutritional implications.

双原子气体一氧化氮(NO)由哺乳动物细胞产生，并用于调节多种生理过程，这一惊人的发现让生物学家们着迷了近40年。NO的生物化学性质复杂，NO生物合成调控及信号转导机制的研究不断涌现。NO是心血管功能、代谢、神经传递、免疫等的关键调节因子，异常的NO信号是许多主要疾病的中心特征，包括心血管疾病、糖尿病和癌症。在这里，我们讨论了NO生物学的基础，强调了该领域的最新进展，包括增加NO生物活性的治疗和营养意义的新手段。