20种癌症分泌的100种自身抗体

癌症分泌自身抗体的作用 

1. 促进癌细胞恶变 癌症分泌的自身抗体具有类似于生长因子的作用，直接促进癌细胞的恶变（包括增殖、迁移、侵袭和抗凋亡）。 2. 促进免疫逃逸 癌症分泌的自身抗体，通过特定的糖基化修饰（如Ans162位点的唾液化修饰），可以从促进免疫作用转变为免疫抑制作用。 这些唾液酸化的IgG分子可以通过与树突状细胞上的唾液酸受体DC-SIGN结合，抑制树突状细胞(DCs)和CD4+T细胞的功能。 癌症细胞分泌抗体可以抑制ADCC功能，下调NK细胞的细胞毒活性。 

3.促肿瘤炎症 在脂多糖(LPS)刺激后，癌症分泌IgG显著上调。 癌症来源的IgG，可以通过 TLR4/TRIF/NF-kB 通路刺激肿瘤相关巨噬细胞释放IL-1b来诱导炎症。

Front. Immunol. 12:613530. 

癌症分泌自身抗体 

1. 头颈部癌 anti-SP17 anti-p53 

2. 中枢神经系统肿瘤 anti-MGMT anti-IGHG4 anti-CRYM  anti-EFCAB2  anti-STAT6  anti-HDAC7A anti-CCNB1 anti-pituitary (APA)  anti-hypothalamus (AHA) 

胃肠道肿瘤 anti-p53 anti-NY-ESO-1 anti-AEG-1 anti-CTAG2,  anti-DDX53,  anti-MAGEC1,  anti-MAGEA3, anti-GPR78 

3. 胃癌 Anti-RaIA anti-c-Myc,  anti-p16,  anti-HSPD1,  anti-PTEN,  anti-p53,  anti-NPM1,  anti-ENO1,  anti-p62,  anti-HCC1.4 anti-ALDH1B1， anti-UQCRC1， anti-CTAG1 anti-CENPF anti-14-3-3ζ 

4. 结直肠癌 anti-p53 anti-c-MYC  anti-cyclin B1  anti-p62  anti-Koc anti-IMP1 anti-survivin anti-RalA  anti-HSP70  anti-Galectin1  anti-KM-HN-1 anti-NY-ESO-1,  anti-p90,  anti-Sui1,  anti-HSP40,  anti-HCC-22-5,  anti-PrxVI,  anti-VEGF, anti-HCA25a,  anti-p62,  anti-Annexin 

5. 胰腺癌 anti-MUC4 anti-PTEN,  anti-EID 3(EP300-interacting inhibitor of differentiation 3)  anti-EH domain-containing protein 1,  anti-galactoside-binding soluble 9,  anti-BRCA1-associated protein 

6. 肝癌 anti-Sui1, anti-p62,  anti-RalA, anti-p53, anti-NY-ESO-1, anti-c-Myc anti-PTCH1、 anti-GNA11、 anti-PAX5、 anti-GNAS、 anti-MSH2、 anti-Survivin anti-HCC1、 anti-P16、 anti-P56、 anti-P90 anti-SPAG9（sperm-associated antigen 9） anti-NY-ESO-1 

7. 食管癌 Anti-TOP48 anti-P16 anti-NY-ESO-1 

8. 甲状腺癌 Anti-Tg（thyroglobulin） 

9. 肺癌

anti-p53, 

anti-NY-ESO-1,

anti-CAGE, 

anti-GBU4-5, 

anti-Annexin 1,

anti-SOX2 , 

anti-HuD, 

anti-MAGE A4 

anti-TOP2A,

anti-ACTR3, 

anti-RPS6KA5, 

anti-PSIP1 

anti-BCL7A, 

anti-TRIM33, 

anti-MTERF4, 

anti-CTAG1A, 

anti-DDX4, 

anti-MAGEC2 

anti-MUC17, 

anti-CAMSAP2,

anti-KIF13B, 

anti-SMG1, 

anti-MED14,

anti-ALMS1, 

anti-GCC2, 

anti-TIMELESS, 

anti-TNS1,

anti-ATP1A4, 

anti-HRNR 

anti-PGP9.5, 

anti-GAGE7, 

anti-GBU4-5, 

anti-MAGE A1, 

anti-CT47A, 

anti-PAGE3, 

anti-VCX, 

anti-MAGEB1,

anti-LIN28B,

10. 乳腺癌

anti-HSP60 anti-PI3K anti-p53 anti-MNRR1 anti-HSPA4 

11. 肾上腺皮质癌 anti-FATE1 

12. 卵巢癌 anti-CA 125 anti-p53 anti-CTAG2 anti-PVR anti-TRIM39 anti-TRIM21 anti-NY-ESO-1 anti-CREB3、 anti-MRPL46、 anti-EXOSC10、 anti-BCOR、 anti-HMGN2、 anti-HIP1R、 anti-OLFM4 anti-KIAA1755， anti-CREB3 anti-PAX8 anti-CCL18  anti-CXCL1 anti-C1D,  anti-TM4SF1,  anti-TIZ,  anti-FXR1 anti-ICAM3,  anti-CTAG2,  anti-STYXL1, anti-POMC,  anti-NUDT11, anti- UHMK1,  anti-KSR1,  anti-NXF3 anti-GRP78 

13. 宫颈癌 anti-GAPDH anti-CA19-9 anti-CA15-3 anti-CEA 

14. 膀胱癌 anti-PPP1CA 

15.前列腺癌 anti-PARC anti-Fetuin-A 

16.睾丸精原细胞瘤 anti-Ta anti-Ma2 

17. 淋巴瘤 anti-Jo-1 anti-Jo-3、 anti-ssDNA、

anti-p-ANCA、

anti-ANA

anti-RF

18. 黑色素瘤 anti-ZBTB7B,  anti-PRKCH,  anti-p53TP53,  anti-PCTK1,  anti-PQBP1, anti-UBE2V1,  anti-IRF4， anti-MAPK8_tv2,  anti-MSN,  anti-TPM1 

19. 血管肉瘤 anti-p53 

20. 抗体介导的副肿瘤综合征 Anti-phospholipid Anti- RI 

主要参考文献

Cui M, Huang J, Zhang S, Liu Q,Liao Q and Qiu X (2021) Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis. Front. Immunol. 12:613530.

Wang, H.; Zhang, B.; Li, X.; Zhou, D.; Li, Y.; Jia, S.; Qi, S.; Xu, A.; Zhao, X.; Wang, J.; et al. Identification and Validation of Novel Serum Autoantibody Biomarkers for Early Detection of Colorectal Cancer and Advanced Adenoma. Front. Oncol. 2020, 10, 1081.

Wang, K.; Li, M.; Qin, J.; Sun, G.; Dai, L.; Wang, P.; Ye, H.; Shi, J.; Cheng, L.; Yang, Q.; et al. Serological Biomarkers for Early Detection of Hepatocellular Carcinoma: A Focus on Autoantibodies against Tumor-Associated Antigens Encoded by Cancer Driver Genes. Cancers 2020, 12.

Perisetti, A.; Bellamkonda, M.; Konda, M.; Edwards, S.; Ali Khan, S.; Bansal, P.; Hu, Z.D.; Goyal, H. Tumor-associated antigens and their antibodies in the screening, diagnosis, and monitoring of esophageal cancers. Eur. J. Gastroenterol. Hepatol. 2020, 32, 779–788

Giovanella, L. Circulating biomarkers for the detection of tumor recurrence in the postsurgical follow-up of differentiated thyroid carcinoma. Curr. Opin. Oncol. 2020, 32, 7–12

Pei, L.; Liu, H.; Ouyang, S.; Zhao, C.; Liu, M.; Wang, T.; Wang, P.; Ye, H.; Wang, K.; Song, C.; et al. Discovering novel lung cancer associated antigens and the utilization of their autoantibodies in detection of lung cancer. Immunobiology 2020, 225, 151891

来源：闲谈 Immunology 2022-03-23