Gestational diabetes mellitus affects millions of pregnant women. Lifestyle intervention is recommended as the first-line treatment, in which exercise plays an important role. Effective and safe exercise is required to facilitate glycaemic control and improve delivery outcomes.
To investigate the efficacy and safety of the original Gymnastics for Pregnant Women program for glycaemic control and delivery outcomes improvement in gestational diabetes mellitus women.
The study was a two-arm parallel randomized controlled clinical trial.
The study was conducted in a tertiary specialized maternity hospital in Hangzhou, China.
Totally 131 eligible pregnant women were enrolled from June to December 2020.
Participants were randomly allocated to the control group (conventional intervention) or experimental group that engaged in the original Gymnastics for Pregnant Women program. The primary outcomes included glycaemic control during pregnancy and postpartum. Secondary outcomes included adverse events, maternal and neonatal outcomes.
Participants showed a significant improvement in glycaemic control after engaging in the intervention for 2 weeks; the improvement was most significant in terms of the 2-h postprandial plasma glucose (P < 0.05). The fasting blood glucose and 2-h postprandial plasma glucose data indicated a higher glycaemic control rate in the experimental than control group (86.16% vs. 66.67%, P = 0.008; and 84.62% vs. 36.36% [6.09 ± 0.79 vs. 6.96 ± 1.06 mmol/L], P < 0.001, respectively). After delivery, the 2-h oral glucose tolerance test results indicated better glycaemic control in the experimental than control group (75.44% vs. 57.41% [6.93 ± 1.44 vs. 7.79 ± 2.03 mmol/L], P = 0.047). Additionally, the 2-h oral glucose tolerance test in the experimental group with reasonable exercise frequency (≥ 10 times per week) had the best glucose level (6.81 ± 1.30 mmol/L), followed by the experimental group with a lower exercise frequency (< 10 times per week) (7.35 ± 1.83 mmol/L) and the control group (7.79 ± 2.03 mmol/L). No statistical differences in maternal or neonatal outcomes were observed between the control and experimental groups (P > 0.05). In addition, there were no adverse events in the experimental group; however, in the control group, two cases experienced at least one hypoglycaemic episode and two cases received insulin during the study period.
The original Gymnastics for Pregnant Women was associated with greater improvements in blood glucose levels during pregnancy and postpartum compared with a conventional intervention for women with gestational diabetes mellitus.
干预2 周后患者血糖控制有明显改善;以餐后2 h血糖改善最为显著(P < 0.05)。空腹血糖和餐后2小时血糖数据显示，试验组血糖控制率高于对照组(86.16% vs. 66.67%， P = 0.008;和84.62%和36.36%[6.09 ± 0.79 vs 6.96 ±1.06 更易/ L), P < 0.001,分别)。分娩后2小时口服糖耐量试验结果显示，试验组血糖控制优于对照组(75.44%∶57.41%[6.93 ± 1.44∶7.79 ± 2.03 mmol/L]， P = 0.047)。此外,实验组2 h口服葡萄糖耐量试验的合理的运动频率(每周≥10次)最好的血糖水平(6.81 ±1.30 更易/ L),紧随其后的是实验组运动频率较低(< 10次/周)(7.35 ±1.83 更易/ L)和对照组(7.79 ±2.03 更易/ L)。对照组与实验组产妇及新生儿结局无统计学差异(P > 0.05)。试验组无不良事件发生;然而，在对照组中，2例至少经历了一次低血糖发作，2例在研究期间接受了胰岛素治疗。
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