在癌症中以铁死亡作为靶点

Targeting ferroptosis as a vulnerability in cancer

（Nat Rev Cancer；IF:60.716）

• Lei G, Zhuang L, Gan B. Targeting ferroptosis as a vulnerability in cancer [published online ahead of print, 2022 Mar 25]. Nat Rev Cancer. 2022

Abstract

Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered enormous interest in cancer research communities, partly because it is a unique cell death modality that is mechanistically and morphologically different from other forms of cell death, such as apoptosis, and therefore holds great potential for cancer therapy. In this Review, we summarize the current understanding of ferroptosis-inducing and ferroptosis defence mechanisms, dissect the roles and mechanisms of ferroptosis in tumour suppression and tumour immunity, conceptualize the diverse vulnerabilities of cancer cells to ferroptosis, and explore therapeutic strategies for targeting ferroptosis in cancer.

铁死亡是一种铁依赖的受调节的程序性细胞死亡，由细胞膜上脂质过氧化物的毒性积聚引发。近年来，铁死亡引起了癌症研究领域的极大兴趣，部分原因是它是一种独特的细胞死亡方式，在机制和形态上不同于细胞凋亡等其他形式的细胞死亡，因此具有巨大的癌症治疗潜力。在这篇综述中，我们总结了目前对铁死亡诱导和铁死亡防御机制的认识，剖析了铁死亡在肿瘤抑制和肿瘤免疫中的作用和机制，提出了癌细胞在铁死亡机制下展现的多种脆弱性，并探讨了靶向铁死亡的癌症治疗策略。

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