认知刺激疗法对痴呆症患者的影响：RCT研究的系统评价和分析

Abstract

Background

Cognitive stimulation therapy (CST) has been used to improve cognitive function and reduce negative emotions. However, the efficacy of CST among the dementia population remains inconclusive.

Aim

To analyze the efficacy of the CST among people with dementia.

Design

Systematic review and meta-analysis.

Methods

A systematic literature search was performed using the Academic Search Complete, CINAHL, EMBASE, MEDLINE, PubMed, OVID (UpToDate), and Web of Science databases from the inception to October 18, 2021. The revised Cochrane risk of bias tool for randomized trials was used to assess the methodological quality of the included studies. A meta-analysis was performed using a random-effects model to calculate the pooled effects of CST. Stata 16.0 was used for statistical analysis.

Results

A total of 26 studies were included. Overall, CST increased cognitive function (standardized mean difference [SMD]: 0.97; 95% confidence interval [CI]: 0.66 to 1.28) and decreased depression (SMD: −0.18; 95% CI: −0.33 to −0.04). No significant effects were found for neuropsychiatric symptoms.

Conclusions

Cognitive stimulation therapy effectively improves cognitive function and alleviates depression levels among people with mild-to-moderate dementia. Futures studies can consider a protocol combined with a rigorous study design to address the effects of CST.

摘要翻译（仅供参考）

背景介绍

认知刺激疗法（CST）已被用于改善认知功能和减少负面情绪。然而，CST在痴呆症人群中的疗效仍无定论。

目的

分析CST在痴呆症患者中的疗效。

设计

系统回顾和荟萃分析。

方法

使用Academic Search Complete、CINAHL、EMBASE、MEDLINE、PubMed、OVID（UpToDate）和Web of Science数据库进行了系统性文献检索，检索时间从开始到2021年10月18日。修订后的Cochrane随机试验偏倚风险工具被用来评估所纳入研究的方法学质量。采用随机效应模型进行荟萃分析，计算CST的集合效应。统计分析使用了Stata 16.0。

结果

共有26项研究被纳入。总体而言，CST增加了认知功能（标准化平均差异[SMD]：0.97；95%置信区间[CI]：0.66至1.28），减少了抑郁（SMD：-0.18；95%CI：-0.33至-0.04）。对神经精神症状没有发现明显的影响。

结论

未来的研究可以考虑将协议与严格的研究设计相结合，以解决CST的效果。

THE

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