RESULTS Data from 132 children were analysed. Melatonin significantly reduced the incidence of emergence delirium compared to placebo: 27 vs. 50%, respectively, an absolute risk reduction of 23.3 [95% confidence interval 3.7 to 42.9), P=0.03]. Melatonin also significantly reduced the risk of emergence delirium compared with midazolam: 27 vs. 56%, respectively, an absolute risk reduction of 29.2 (95% CI 9.5 to 48.8). The midazolam group had a similar incidence of emergence delirium as placebo. Sedation scores were similar in the three groups postoperatively. The incidence and score of pre-operative anxiety as well as the compliance with mask induction were similar in the three groups.
结果：对132名儿童的资料进行了分析。与安慰剂相比，褪黑素显著降低了苏醒期谵妄的发生率：分别为27%和50%，绝对风险降低23.3[95%置信区间3.7 - 42.9），P=0.03]。与咪达唑仑相比，褪黑素也显著降低了苏醒期谵妄的发生风险：分别为27%和56%，绝对风险降低29.2（95%置信区间9.5 - 48.8）。咪唑安定组苏醒期谵妄的发生率与安慰剂组相似。三组术后镇静评分相似。三组患者术前焦虑的发生率和评分以及对面罩诱导的依从性相似。