BMJ发表基于护士队列研究:美国女性个人使用永久染发剂与的癌症风险和死亡率的关系

2020
12/01

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BMJ发表基于护士队列研究:个人使用永久染发剂与大多数癌症风险和与癌症相关的死亡率之间没有发现正相关。

BMJ发表基于护士队列研究:

美国女性个人使用永久染发剂与癌症风险和死亡率的关系:前瞻性队列研究

 82401605309042807  

81901605309042852

摘要

目的:评估个人使用永久染发剂与癌症风险和死亡率之间的关联。

设计: 前瞻性队列研究。

背景和参与者:117 200名女性参加了“护士健康研究”,这是一项针对美国女护士正在进行的前瞻性队列研究。这些女性在基线时没有罹患癌症,并报告有关个人使用永久染发剂的信息,持续随访了36年。

暴露:永久染发剂的状态,持续时间,频率和整体使用量(根据持续时间和频率计算的累积剂量)。自首次使用永久染发剂的年龄以及累计使用时间。

主要结果指标:个人使用永久染发剂与患上整体癌症和特定癌症的风险以及与癌症相关的死亡之间的关联。通过使用Cox比例风险模型估算年龄和多变量调整后的危险比以及95%置信区间。

结果:与未使用者相比,永远使用永久染发剂的人罹患实体癌(n = 20805,不包括非黑素瘤皮肤癌;危险比0.98,95%置信区间0.96-1.01)或整体造血癌(n = 1807;1.00,0.91至1.10)的风险均没有显著增加。此外,从未使用者大多数特定癌症相关的死亡风险(n =4860;0.96,0.91至1.02)并没有显著增加。曾经使用者的基底细胞癌风险略有增加(n = 22 560;1.05,1.02至1.08)。累积剂量与雌激素受体阴性乳腺癌,孕激素受体阴性乳腺癌,激素受体阴性乳腺癌和卵巢癌的风险呈正相关。仅具有自然深色头发的女性(根据70名女性,有24个具有深色头发的女性)观察到霍奇金淋巴瘤的风险增加,而具有自然浅色头发的女性患基底细胞癌的风险较高。

结论:个人使用永久染发剂与大多数癌症风险和与癌症相关的死亡率之间没有发现正相关。但基底细胞癌/乳腺癌(雌激素受体阴性,孕激素受体阴性,激素受体阴性)和卵巢癌的风险增加,在以自然发色分层的分析中混杂的发现值得进一步研究。

  82401605309042807  

英文摘要

Objective:  To evaluate the associations between personal use of permanent hair dyes and cancer risk and mortality.

Design:  Prospective cohort study.

Setting and participants:  117 200 women enrolled in the Nurses' Health Study, an ongoing prospective cohort study of female nurses in the United States. The women were free of cancer at baseline, reported information on personal use of permanent hair dyes, and were followed for 36 years.

Exposure:  Status, duration, frequency, and integral use (cumulative dose calculated from duration and frequency) of permanent hair dyes. Age at first use and time since first use of permanent hair dyes.

Main outcome measures:  Associations of personal use of permanent hair dyes with risk of overall cancer and specific cancers, and cancer related death. Age and multivariable adjusted hazard ratios and 95% confidence intervals were estimated by using Cox proportional hazard models.

Results:  Ever users of permanent hair dyes had no significant increases in risk of solid cancers (n=20 805, excluding non-melanoma skin cancers; hazard ratio 0.98, 95% confidence interval 0.96 to 1.01) or hematopoietic cancers overall (n=1807; 1.00, 0.91 to 1.10) compared with non-users. Additionally, ever users did not have an increased risk of most specific cancers (cutaneous squamous cell carcinoma, bladder cancer, melanoma, estrogen receptor positive breast cancer, progesterone receptor positive breast cancer, hormone receptor positive breast cancer, brain cancer, colorectal cancer, kidney cancer, lung cancer, and most of the major subclasses and histological subtypes of hematopoietic cancer) or cancer related death (n=4860; 0.96, 0.91 to 1.02). Basal cell carcinoma risk was slightly increased for ever users (n=22 560; 1.05, 1.02 to 1.08). Cumulative dose was positively associated with risk of estrogen receptor negative breast cancer, progesterone receptor negative breast cancer, hormone receptor negative breast cancer, and ovarian cancer. An increased risk of Hodgkin lymphoma was observed only for women with naturally dark hair (based on 70 women, 24 with dark hair), and a higher risk of basal cell carcinoma was observed for women with naturally light hair.

Conclusion:  No positive association was found between personal use of permanent hair dye and risk of most cancers and cancer related mortality. The increased risk of basal cell carcinoma, breast cancer (estrogen receptor negative, progesterone receptor negative, hormone receptor negative) and ovarian cancer, and the mixed findings in analyses stratified by natural hair color warrant further investigation. 

本文由作者自行上传,并且作者对本文图文涉及知识产权负全部责任。如有侵权请及时联系(邮箱:nanxingjun@hmkx.cn
关键词:
cancer,染发剂,BMJ,前瞻性,死亡率,队列

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