翻译：冯玉蓉 编辑：冯玉蓉 审校：曹莹
结果：在麻醉诱导过程中，E组血流动力学参数变化小于P组。与丙泊酚相比，依托咪酯的平均LOC时间更短(129.5 s vs 189.5 s, P<0.0001)。LOC时E组的BIS低于P组(46.3 vs 52.9, P=0.0141)。LOC时E组保留自主呼吸的患者多于P组(80% vs 17.5%, P<0.0001)。同样，E组存在角膜反射的患者多于P组(34例vs 4例，P<0.0001)。依托咪酯诱发肌阵挛的发生率为17.5%。
文献来源：Zheng H, Zhu Y, Chen K, et al. The effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study.[J]. Drug Des Devel Ther. 2020 Jun 5;13:1941-1946. doi: 10.2147/DDDT.S211523. eCollection 2020.
The effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study
Purpose: To compare the effect of etomidate versus propofol infusion on hemodynamic profiles, spontaneous breathing, and corneal reflex during the induction of anesthesia.
Methods: Adult patients (n=80) were randomized to receive etomidate (Group E, n=40) or propofol (Group P, n=40) infusion during anesthesia induction. Throughout induction, mean blood pressure and heart rate were monitored. Time to loss of consciousness (LOC), bispectral index (BIS), existence of spontaneous breathing, and corneal reflex at LOC were recorded.
Results: Fewer changes in hemodynamic profile occurred in Group E compared with Group P during induction of anesthesia. The mean time to LOC was shorter with etomidate than propofol (129.5 s vs 189.5 s, P<0.0001). BIS was lower in Group E compared with Group P at LOC (46.3 vs 52.9, P=0.0141). More patients exhibited spontaneous breathing in Group E compared with Group P at LOC (80% vs 17.5%, P<0.0001). Similarly, more patients maintained corneal reflex in Group E compared with Group P (34 patients vs 4 patients, P<0.0001). The incidence of etomidate-induced myoclonus was 17.5%.
Conclusion: Compared with propofol infusion, etomidate infusion during anesthesia induction had fewer effects on the hemodynamic profile of patients. Among patients who received etomidate, the BIS value was lower at LOC, and more patients displayed spontaneous breathing and corneal reflex.