炎症与认知功能

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多个研究发现炎症与认知功能损害有关，也是术后认知功能障碍的潜在机制之一。这篇发表在J Neuroimmunol.杂志的最新文章The Association Between Systemic Inflammation and Cognitive Performance in Healthy Adults以健康成人为研究群体对此进行了进一步的研究。

摘要译文

健康成人全身炎症与认知功能的关系

背景：一些研究表明，轻度全身炎症与认知障碍的风险有关。然而，并不是所有的认知领域与健康人的外周炎症相关性都被评估。因此，我们旨在探讨作为外周炎症标志物的C-反应蛋白（CRP）与健康成人不同认知领域的关系。

方法：采用“莱比锡心身情感互动研究”（LEMON）数据库，对216名德国本地健康成人（男138名，女78名，平均年龄39.12±20.19岁）进行研究。在进行初步评估和认知测试后，采集血样并评估CRP水平。根据CRP水平将患者分为三组。随后，对三组人群的人口学和认知特征进行比较，并应用一般线性模型（GLM）确定CRP水平与认知能力之间的关系。

结果：所有加州语言学习任务（CVLT）评估的记忆成绩与CRP水平呈负相关，其中一些在年龄、性别、教育程度、吸烟状况和体重指数调整后仍然显著。此外，GLM分析显示，注意表现警觉性测试（TAP-A）的平均反应时间（有和无信号）也与CRP水平显著相关。

结论：目前的研究表明，CRP水平较高的健康受试者在言语学习记忆和一般认知觉醒领域表现较差。

关键词：C反应蛋白；认知；记忆。

原文摘要

The Association Between Systemic Inflammation and Cognitive Performance in Healthy Adults

Background: Several studies have indicated that mild systemic inflammation is associated with the risk of cognitive impairment. However, not every cognitive domain has been evaluated to have a correlation with peripheral inflammation in healthy individuals. Therefore, we aimed to investigate the association between C-reactive protein (CRP) as a marker of peripheral inflammation with various domains of cognition in healthy adults.

Method: This study consisted of 216 healthy native German adults (138 males and 78 females, mean age: 39.12 ± 20.19 years) from "Leipzig Study for Mind-Body-Emotion Interactions" (LEMON) database. After the initial assessment and conducting the cognitive battery, a blood sample was collected and CRP level was evaluated. Patients were categorized into three groups based on their CRP level. Subsequently, demographic and cognitive features were compared across three groups and to confirm the association between CRP level and cognitive performance, general linear models (GLM) were applied.

Results: All California Verbal Learning Task (CVLT)-evaluated aspects of memory performance were inversely associated with CRP level, some of which remained significant after the adjustment for age, gender, education, smoking status and body mass index. Moreover, GLM analysis indicated that mean reaction time of the Test of Attentional Performance-Alertness (TAP-A) test (with and without signal) was also significantly associated with CRP level.

Conclusion: The current study indicated that healthy subjects with higher levels of CRP exhibit poorer performance in verbal learning memory and general wakefulness domains of cognition.

Keywords: C-reactive protein; Cognition; Memory.

Ashraf-Ganjouei A, Moradi K, Bagheri S, Aarabi MH. The association between systemic inflammation and cognitive performance in healthy adults [published online ahead of print, 2020 May 25]. J Neuroimmunol. 2020;345:577272. doi:10.1016/j.jneuroim.2020.577272

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