Lim JA, Oh CS, Yoon T G, Lee JY,et al. The eff ect of propofol and sevoflurane on cancer cell, natural killer cell, and cytotoxic T lymphocyte function in patients undergoing breast cancer surgery: an in vitro analysis.[J]. BMC Cancer , Non-U.S. Gov't DOI：10.1186/s12885-018-4064-8
Background: To clarify the effect of anaesthetic agents on cancer immunity, we evaluated the effects of propof ol and sevoflurane on natural killer (NK) cell, cytotoxic T lymphocyte (CTL) counts and apoptosis rate in breast cancer and immune cells co-cultures from patients who underwent breast cancer surgery.
Methods: Venous blood samples were collected after inducing anaesthesia and at 1 and 24 h postoperatively in patients who had undergone breast cancer surgery. The patients were allocated randomly to the propofol- or sevoflurane-based anaesthesia groups.We counted and detected apoptosis in cancer cell, NK cell and CTL of patients with breast cancer by co-culture with a breast cancer cellline in both groups. We also evaluated changes in the cytokines tumour necrosis f actor-alpha, interleukin (IL)-6 and IL-10 during the perioperative period.
Results: Forty-four patients were included in the final analysis. No difference in NK cell count, CTL count or apoptosis rate was detected between the groups. Furthermore, the number of breast cancer cells undergoing apoptosis in the breast cancer cell cocultures was not diff erent between the groups. No changes in cytokines were detected between the groups.
Conclusion: Although basic science studies have suggested the potential benefits of propofol over a volatile agent during cancer surgery, propofol was not superior to sevoflurane, on the aspects of NK and CTL cells counts with apoptosis rate including breast cancer cell, during anaesthesia f or breast cancer surgery in a clinical environment.
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