While lung cancer screening has been extensively studied over the last two decades, the long-term duration and time interval of low-dose CT in lung cancer screening remains unclear.
In an article published online inRadiology (RSNA.org/Radiology), John Kavanagh, FFR, RCSI, University Health Network, Toronto Canada, and colleagues studied the incidence of lung cancer in a cohort of patients with negative findings at previous lung cancer screening.
Of those who were part of the International Early Lung Cancer Action Program screening study between 2003 and 2009, 4,782 were identified with negative screening results, which was defined as no solid nodules greater than 5 mm and no nonsolid nodules greater than 8 mm at the close of the study.
Starting with those at highest risk, identified by factors including age, smoking history, body mass index, family history of lung cancer, years since smoking cessation and diagnosis of chronic obstructive pulmonary disease, 327 participants were contacted and 200 underwent low-dose CT.
The median time since previous CT was seven years. The incidence rate of developing lung cancer during the next six years was estimated at 5.6 percent. The period prevalence of lung cancer was 20.8 percent (new and preexisting lung cancer, 68 of 327). The detection rate of low-dose CT was 7 percent (14 of 200 subjects). Of the 14 screening-detected cancers, 12 were stage I or II.
“Our study shows that high-risk individuals have a high incidence of lung cancer after previous negative low-dose CT examinations and, therefore, that screening should continue beyond three years. The definition of the optimum screening interval may be different for various groups of individuals and will be the subject of future studies,” the authors conclude.
1. cessation [sɛˈseʃən] n. （暂时）停止
2. punctate ['pʌŋkteɪt] adj. 有小刻点的，点状的
3. spiculate ['spɪkjəˌleɪt] adj. 针状的
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