研究肿瘤生态系统的微工程和纳米工程方法

SCI

11 July 2023

Micro-engineering and nano-engineering approaches to investigate tumour ecosystems

(Nature Reviews Cancer, IF: 78.5)

Mijin Kim, Magdalini Panagiotakopoulou, Chen Chen, Stephen B. Ruiz, Karuna Ganesh, Tuomas Tammela & Daniel A. Heller

CORRESPONDENCE TO: hellerd@mskcc.org

Abstract 摘要

The interactions among tumour cells, the tumour microenvironment (TME) and non-tumour tissues are of interest to many cancer researchers. Micro-engineering approaches and nanotechnologies are under extensive exploration for modelling these interactions and measuring them in situ and in vivo to investigate therapeutic vulnerabilities in cancer and extend a systemic view of tumour ecosystems. Here we highlight the greatest opportunities for improving the understanding of tumour ecosystems using microfluidic devices, bioprinting or organon- a-chip approaches. We also discuss the potential of nanosensors that can transmit information from within the TME or elsewhere in the body to address scientific and clinical questions about changes in chemical gradients, enzymatic activities, metabolic and immune profiles of the TME and circulating analytes. This Review aims to connect the cancer biology and engineering communities, presenting biomedical technologies that may expand the methodologies of the former, while inspiring the latter to develop approaches for interrogating cancer ecosystems.

肿瘤细胞、肿瘤微环境（TME）和非肿瘤组织之间的相互作用是许多癌症研究人员感兴趣的问题。目前正在对微工程方法和纳米技术进行广泛的研究，以模拟肿瘤环境中的相互作用，并在原位和患者体内测量这些相互作用，以研究癌症的治疗脆弱性，并扩展肿瘤生态系统的系统观点。在这里，我们强调了使用微流体设备、生物打印或有机芯片方法提高对肿瘤生态系统的理解。我们还讨论了纳米传感器的潜力，该传感器可以从TME内部或身体其他地方传输信息，以解决有关TME和循环分析物的化学梯度、酶活性、代谢和免疫谱变化的科学和临床问题。本综述旨在将肿瘤生物学和工程学联系起来，介绍生物医学技术，这些技术可能会扩展肿瘤生物学方法，同时鼓励工程学开发探究肿瘤生态系统的方法。