转移

SCI

12 May 2023

Metastasis

(IF: Cell, 66.85)

Gerstberger S, Jiang Q, Ganesh K. Metastasis. Cell. 2023 Apr 13;186(8):1564-1579. 

Correspondence: ganeshk@mskcc.org

Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still emerging. Metastasis requires the acquisition of a succession of traits to disseminate, variably enter and exit dormancy, and colonize distant organs. The success of these events is driven by clonal selection, the potential of metastatic cells to dynam-ically transition into distinct states, and their ability to co-opt the immune environment. Here, we review the main principles of metastasis and highlight emerging opportunities to develop more effective therapies for metastatic cancer.

大多数癌症相关死亡都是由于转移引起的，然而我们对转移作为一种不断进化中的、异质性的、全身性的疾病，以及如何对其进行有效治疗的认识仍在不断加深。转移需要获得一系列特征来传播，可变地进入和退出休眠，并定殖于远处的器官。这些事件的成功是由克隆选择、转移细胞动态过渡到不同状态的潜力以及它们选择免疫环境的能力驱动的。在这里，我们回顾了转移的主要原理，并强调了为转移性癌症开发更有效疗法的新兴机会。