精准肿瘤学的转化挑战

The translational challenges of precision oncology

（Cancer Cell；IF:35.455）

• Pich O, Bailey C, Watkins TBK, Zaccaria S, Jamal-Hanjani M, Swanton C. The translational challenges of precision oncology. Cancer Cell. 2022

• CORRESPONDENCE TO : charles.swanton@crick.ac.uk

Abstract | 

The translational challenges in the field of precision oncology are in part related to the biological complexity and diversity of this disease. Technological advances in genomics have facilitated large sequencing efforts and discoveries that have further supported this notion. In this review, we reflect on the impact of these discoveries on our understanding of several concepts: cancer initiation, cancer prevention, early detection, adjuvant therapy and minimal residual disease monitoring, cancer drug resistance, and cancer evolution in metastasis. We discuss key areas of focus for improving cancer outcomes, from biological insights to clinical application, and suggest where the development of these technologies will lead us. Finally, we discuss practical challenges to the wider adoption of molecular profiling in the clinic and the need for robust translational infrastructure.

精准肿瘤学领域中的转化挑战一定程度上与这类疾病的生物学复杂性和多样性相关。基因组学技术的进步促进了大规模测序工程和相关发现，进一步支持了这一概念。在这篇综述中，我们回顾了这些发现对以下几个概念的理解的影响：癌症起始、癌症预防、早期检测、辅助治疗和微小残留病灶监测、癌症耐药性和癌症在转移中的演变。我们讨论了改善癌症结果的关键领域，从生物学视角到临床应用，并建议这些技术的发展将引领我们走向何方。最后，我们讨论了在临床中更广泛地应用分子分析的实际挑战以及对相应转化基础设施的需求。