癌症的早期检测

SCI

19 April 2022

Early detection of cancer

（Science；IF:47.728）

Crosby D, Bhatia S, Brindle KM, et al. Early detection of cancer. Science. 2022

CORRESPONDENCE TO : david.crosby@cancer.org.uk; sb10031@cam.ac.uk

Abstract |

Survival improves when cancer is detected early. However, ~50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome. It is vital to better understand who is at greatest risk of developing cancer. We also need to elucidate the biology and trajectory of precancer and early cancer to identify consequential disease that requires intervention. Insights must be translated into sensitive and specific early detection technologies and be appropriately evaluated to support practical clinical implementation. Interdisciplinary collaboration is key; advances in technology and biological understanding highlight that it is time to accelerate early detection research and transform cancer survival.

患者的生存会因癌症的早期诊断而改善。然而，约50%的癌症在确诊时已处于进展期。癌症或癌前病变的早期检测使早期干预以尝试减缓或预防癌症的发展和致死率成为可能。为了实现所有癌症的早期检测，许多挑战有待克服。更准确地了解罹患癌症的风险人群至关重要。我们还需要阐明癌前病变和早期癌症的生物学性质和轨迹，以确定需要干预的后续疾病。我们对癌症的理解必须转化为具有敏感性和特异性早期检测技术，并进行适当的评估以支持实际的临床实施。跨学科合作是关键；在科学技术和生物学理解方面的进步表明，现在是加速早期检测研究和改变癌症生存的合适时机。