CAR-T里程碑专利，及全球概况

CAR-T里程碑式专利

WO2005044996

St. Jude Children's Research Hospital 

Chimeric receptors with 4-1BB stimulatory signaling domain

US9834590

St. Jude Children's Research Hospital

Chimeric receptors with 4-1BB stimulatory signaling domain

WO2007059298

City of Hope

Chimeric immunoreceptor useful in treating human cancers

WO2008043777

University of Nantes

Use of monoclonal antibodies specific to the O-acetylated form of GD2 ganglioside for the treatment of certain cancers

WO2008121420

Memorial Sloan Kettering Cancer Center

Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes

WO2009091826

University of Texas System

Compositions and methods related to a human CD19-specific chimeric antigen receptor (h-CAR)

WO2011056894

City of Hope

Truncated epidermal growth factor receptor (EGFRt) for transduced T cell selection

WO2012079000

University of Pennsylvania

Use of chimeric antigen receptor modified T-cells to treat cancer

WO2012129514

Fred Hutchinson Cancer Research Center

Method and compositions for cellular immunotherapy

WO2013123061

Seattle Children's Hospital

Bispecific chimeric antigen receptors and encoding polynucleotides thereof

WO2014153270

Novartis and University of Pennsylvania

Treatment of cancer using humanized anti-CD19 chimeric antigen receptor

WO2015142675

Novartis and University of Pennsylvania

Treatment of cancer using chimeric antigen receptor

WO2017025038

Legend Biotech

Chimeric antigen receptors based on single-domain antibodies and methods of use thereof

WO2017172981

University of Southern California

Chimeric antigen receptors targeting cancer

WO2019076149

Chongqing Precision Biotech

Universal CAR-T cell preparation, method therefor and application thereof

CN109055380

Fapon Biopharma

A preparation method for universal CAR-T cells

喵评：中国CAR-T细胞治疗飞速发展，并逐渐成为全球第一梯队。南京传奇，上海科济，重庆精准等逐渐获得一席之地。

参考文献：

Liyang Lyu et al，The global chimeric antigen receptor T (CAR-T) cell therapy patent landscape，Nat Biotechnol . 2020 Dec;38(12):1387-1394.