重复流产的多因素研究

作者：eIVF net

链接：http://news.eivf.net/blog/2016/3/16/Why-Do-Multiple-Miscarriages-Occur

我们都听到过类似的统计数据：多达四分之一的妊娠以流产结束。但是，尽管流产很常见，当它发生时仍然令人难以接受。很多女人有重复流产的经历，不难想象这将造成多少痛苦。因此，当英国华威大学的研究人员认为他们已经找到重复流产发生的原因时，这个消息是多么令人振奋。有人希望，这一发现可以被用来研究新的疗法，从而在怀孕的最初期就防止流产的发生。

科学家们相信，当子宫内膜里的干细胞出现缺乏时，有可能会导致复发性流产（复发性流产被定义为三次及以上连续的流产经历）。他们的研究发表在最近一期的《干细胞》杂志上。研究人员检查了183名曾经历过多次流产的女性的子宫内膜，发现他们缺少一个“表观遗传指纹”--即预示干细胞存在的某种信号。“我们已经发现，即使在怀孕之前，这些患者的子宫内膜就已经有了缺陷”，该研究的第一作者Jan Brosens说。

那么，对患有复发性流产的妇女来说，这意味着什么呢？妇产科教授Brosens认为该发现可能帮助一些患者找到治愈的疗法。“我可以设想，我们可以在患者尝试下一次受孕之前来纠正这些缺陷”，Brosens说。该研究的共同作者Siobhan Quenby说：“对于相关新型治疗方法的研究将在今年开始进行。在2016年春季，我们就将开始试验新的干预措施以便改善子宫内膜的状况。”她还说，该小组的研究重点将是双重的：“首先，我们希望通过设计新的子宫内膜测试来提高对妇女复发性流产风险的成功筛查率。其次，有一些药物或者干预措施有可能增加子宫内膜内干细胞的数量。例如，子宫内膜“刮擦”这一通常被用来使胚胎移植更成功的程序便可能有上述效果。

Why Do Multiple Miscarriages Occur?

Miscarriages are very upsetting, and overall can really be a struggle to deal with. According to todaysparent.com, scientists believe they have found a solution to why this occurs. 

Here is the rest of the article!!!

We’ve all heard the stat: As many as one in four pregnancies ends in miscarriage. But despite how common miscarriage is, it hurts like hell when it happens. It did for me, anyway. I lost a baby at 13 weeks—it had died at 9 weeks, but I only found out a month later, when I started bleeding—and the experience is easily the hardest thing I’ve ever been through in my life.

But I only had one miscarriage. Lots of women have multiple miscarriages, which I can imagine would be almost unbearable. That’s why it’s really exciting to hear that researchers at the University of Warwick in the UK think they’ve figured out the reason why some multiple miscarriages happen—which, hopefully, could lead to the discovery of a method of preventing it in the first place.

The scientists believe that a lack of stem cells in the womb lining could be cause of recurrent miscarriages (defined as the loss of three or more consecutive pregnancies). For their study, which was published in a recent issue of the journal Stem Cells, they looked at the womb linings of 183 women who had experienced multiple losses and found that they were missing an “epigenetic signature”—something that signals the presence of stem cells. “We have discovered that the lining of the womb in the recurrent miscarriage patients we studied is already defective before pregnancy,” says lead study author Jan Brosens. (Personally, I think the use of the word “defective” here is kind of hurtful, but I get what he’s saying.)

So what does this mean for women suffering from recurrent miscarriages? Brosens, who is a professor of Obstetrics & Gynaecology, thinks the discovery could lead to a cure for some patients. “I can envisage that we will be able to correct these defects before the patient tries to achieve another pregnancy.”

Study of new treatments will get underway this year, says study co-author Siobhan Quenby. “We will start piloting new interventions to improve the lining of the womb in the spring of 2016.”

The team’s focus will be twofold, she says. “First, we wish to improve the screening of women at risk of recurrent miscarriage by developing new endometrial tests. Second, there are a number of drugs and other interventions, such as endometrial ‘scratch’, a procedure used to help embryos implant more successfully, that have the potential to increase the stem cell populations in the womb lining.”

As someone who’s been through a miscarriage, I’m glad to know the issue is being studied and that there are discoveries being made. The fact that miscarriages are common doesn’t make them any easier to stomach. Lots of health issues are common, but doesn’t mean we should accept them as inevitable.

（文章来自沈阳九州家圆医院官方网站）