新研究证实大麻对男性生育能力的影响

作者: Hibz Y.D. 

链接：http://news.islandcrisis.net/2016/04/marijuana-can-affect-male-fertility-suggests-new-study/

根据发表在FASEB杂志上的一项新研究，大麻也可能对男性精子产生有害作用。

一项本意在于提高男性生育能力的研究发现一种叫做CB2的大麻素受体与精子生成的过程有关。研究人员解释说，这一发现表明，大麻可能会破坏男性的生育能力。

由意大利罗马大学Paola Grimaldi领导的研究团队让实验小鼠服用不同的药物，其中一组服用CB2受体的活化剂，另一组则服用CB2受体抑制剂，第三组作为对照组只服用生理盐水。研究结果表明，服用CB2活化剂的小鼠有更快的生精速率，而服用CB2抑制剂的小鼠则显示了相反的效果并有较慢的精子产生率。这些结果表明，CB2的激活需要维持一定的平衡状态以保证正确的精子产生过程。

FASEB杂志的主编Thoru Pederson指出，这项研究有可能为男性不育症的治疗开辟新的研究方向。他还说：“内源性大麻素对精子正常产生会有正面效果，如果采用可以进一步激发这种效果的激动剂，有可能发展出治疗男性不育症的一些新疗法”。

Marijuana Can Affect Male Fertility, Suggests New Study

The study focusing mainly on finding ways to enhance male fertility has found that a ‘marijuana receptor’ called CB2 (a cannabinoid receptor) is linked with the regulation of sperm production (a process named spermatogenesis). This might sound like good news, but the researchers of the study explain that this finding indicates that marijuana might thus be disrupting male fertility.

Led by Paola Grimaldi from the University of Rome Tor Vergata, Italy, the team treated mice with different agents: one group, with an activator of the CB2 receptor; another with an inhibitor of the same receptor; a third group acting as the control one received only a saline solution.

The findings show that the CB2 activator group had a more rapid rate of spermatogenesis while the inhibitor group displayed the opposite effect as they had a slower rate of sperm production. These results suggest that CB2 activation is needed to be in a certain balance for spermatogenesis to occur properly and adequately.

This research might be opening up new doors for the treatment of male infertility, as pointed out by the Editor-in-Chief of The FASEB Journal, Thoru Pederson. According to the latter, “the normal beneficial effects of endogenous cannabinoids on spermatogenesis can be stimulated further by a chemical mimic, an agonist, is a potentially promising new idea for treating male infertility“.

（文章来自沈阳九州家圆医院官方网站）